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Director, Biology and Translational Research
San Francisco, CA Hybrid

GondolaBio is a clinical-stage biopharmaceutical company focused on developing next-generation therapeutics for genetic diseases. Originally launched as BridgeBioX, a subsidiary of BridgeBio, GondolaBio secured $300M in private financing from external investors in 2024 and became an independent company within the BridgeBio ecosystem. The company aims to leverage cutting-edge biological research to create breakthrough medicines addressing high unmet needs across multiple therapeutic areas, including neurology, pulmonology, cardiology, nephrology, and endocrinology. Located on the Stanford Life Sciences campus, GondolaBio fosters a unique hybrid environment where top scientists from around the world collaborate with senior leadership and advisors, blending industry expertise with academic innovation.

About BridgeBio

BridgeBio is a biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. Founded in 2015, the company has built a portfolio of 20+ drug development programs ranging from preclinical to late-stage development in multiple therapeutic areas including genetic dermatology, precision oncology, cardiology, endocrinology, neurology, pulmonology, and renal disease, with two approved drugs.

We seek an entrepreneurial scientist to drive the biology and translational research for Portal Therapeutics. You will lead scientific strategy and direction, assay development, mouse model experimentation, preclinical dose guidance, regulatory document writing including INDs, and other translational biology and pharmacology experiments through a combination of internal and external efforts. This job requires excellent communication and interpersonal skills as well as technical and scientific abilities. We hope to hear from you.

Responsibilities

• Lead the biology, pharmacology, and translational research for Portal
• Develop deep understanding of the biology and pharmacology of the relevant disease area and treatment approaches
• Responsible for generating comprehensive biology and pharmacology package
• Design, execute, and interpret preclinical studies to address mechanism of action and translational pharmacology studies (in vitro and in vivo)
• Manage relationships with CROs for efficient execution of all the preclinical and translational studies
• Collaborate with cross-functional teams, including DMPK, toxicology, clinical development and regulatory to advance our therapeutic candidates from preclinical stages toward clinical development
• Develop scientific publications, abstracts, and posters, and investor and layperson-facing materials on the Portal program
• Evaluate expansion indications or additional therapy opportunities
• Represent the program scientifically to internal and external audiences
• Manage research associate or scientist-level individuals as needed
• Contribute to the drafting of translation- and pharmacology-related sections of regulatory documents including INDs
• Contribute to due diligence and gap analysis on potential new GondolaBio assets

No matter your role at BridgeBio, successful team members are:

• Patient Champions, who put patients first and uphold strict ethical standards
• Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset
• Truth Seekers, who are detailed, rational, and humble problem solvers
• Individuals Who Inspire Excellence in themselves and those around them
• High-quality executors, who execute against goals and milestones with quality, precision, and speed

Education, Experience & Skills Requirements

• Ph.D., MD, or Ph.D./MD degree and expertise in a relevant scientific field with 6+ years of related work experience in pharma or biotech environment
• Strong scientific background and achievements in bioscience and translational, ideally demonstrated by scientific publications, presentations, and/or patents
• Proven track record of successfully leading research programs and teams
• Strong understanding of drug discovery and development processes
• Excellent communication, leadership, and organizational skills
• Ability to think strategically and execute effectively
• Experience in collaborating with cross-functional teams and external partners
• Knowledge of regulatory requirements and industry standards
• Demonstrate creative 'out of the box' thinking to solve complex technical problems and champion innovative technologies to achieve project goals
• Commitment, drive, and ownership mindset

What We Offer

• Patient Days, where we hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts
• A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak
• A de-centralized model that enables our program teams to focus on advancing science and helping patients.
• A place where you own the vision – both for your program and your own career path
• A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game
• Access to learning and development resources to help you get in the best professional shape of your life
• Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
• Flexible PTO
• Rapid career advancement for strong performers
• Commitment to Diversity, Equity & Inclusion

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